Mutants of GAL4 protein altered in an activation function
نویسندگان
چکیده
منابع مشابه
Analysis of Gal4-directed transcription activation using Tra1 mutants selectively defective for interaction with Gal4.
Promoter-specific transcriptional activators (activators) stimulate transcription through direct interactions with one or more components of the transcription machinery, termed the "target." The identification of direct in vivo targets of activators has been a major challenge. Previous studies have provided evidence that the Tra1 subunit of the yeast SAGA (Spt-Ada-Gcn5-acetyltransferase) comple...
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Most proteins that activate RNA polymerase II-mediated transcription in eukaryotic cells contain sequence-specific DNA-binding domains and "activation" regions. The latter bind general transcription factors and/or coactivators and are required for high-level transcription. Their function in vivo is unknown. Since several activation domains bind the TATA-binding protein (TBP), TBP-associated fac...
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ژورنال
عنوان ژورنال: Cell
سال: 1987
ISSN: 0092-8674
DOI: 10.1016/0092-8674(87)90016-x